Testing & Tracking
Compounds & Therapies
Apomorphine for Erectile Dysfunction
Apomorphine is a non-selective dopamine receptor agonist with a long history in medicine — originally used as an emetic in poisoning treatment, more recently in Parkinson's disease management (subcutaneous Apokyn, sublingual Kynmobi). For erectile…
Cabergoline: A Practical Guide
Overview Cabergoline (Dostinex®) is a long-acting, highly selective dopamine D2 and D3 receptor agonist derived from ergot alkaloids. It is FDA-approved for treatment of hyperprolactinemia — excess prolactin production, which suppresses the hypothalamic-pituitary-gonadal (HPG) axis, causing…
Citrulline (L-Citrulline)
Amino acid nitric oxide precursor for vascular function and athletic performance
Enclomiphene
The Active Isomer of Clomiphene for Testicular Function Preservation
Fadogia Agrestis
A traditional West African plant with limited regulatory guidance and concerning preclinical safety signals requiring clinical oversight
Gonadotropin Guide
HCG (Human Chorionic Gonadotropin)
Oxytocin
The Bonding and Trust Hormone for Social and Intimate Function
PT-141 (Bremelanotide)
FDA-Approved Melanocortin Agonist (Women Only)
PT-141 (Bremelanotide): A Practical Guide
Overview PT-141 (bremelanotide; synthetic amino acid sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) is
Sildenafil (Viagra)
The Original Phosphodiesterase-5 Inhibitor for Erectile Function
SSRIs — Long-Term Use and PSSD
Selective serotonin reuptake inhibitors (SSRIs) — fluoxetine, sertraline, citalopram, escitalopram, paroxetine, fluvoxamine — and the closely related SNRIs (venlafaxine, duloxetine) are among the most-prescribed medication classes in modern…
Tadalafil (Cialis)
The Long-Acting Phosphodiesterase-5 Inhibitor for Erectile Function and Hemodynamics
Testosterone
The Gold Standard in Male Hormone Optimization
Tongkat Ali (Eurycoma longifolia)
Traditional Southeast Asian herbal root extract for testosterone and vitality support
Trimix Injections
Trimix is a compounded intracavernosal injection containing three vasoactive drugs: alprostadil (a prostaglandin E1 analog), papaverine (a smooth-muscle relaxant), and phentolamine (an alpha-adrenergic antagonist). Self-administered by…
Procedures & Modalities
Pelvic Floor Physical Therapy for Men
Pelvic floor physical therapy (PFPT) for men is one of the most under-prescribed, under-recognized evidence-based interventions in men's health. The male pelvic floor — including the levator ani, coccygeus, and supporting muscle groups — is integral…
Shockwave Therapy (ESWT)
Device-regulated; FDA-approved (PMA) for plantar fasciitis and lateral epicondylitis; emerging use for vascularity and ED
Protocols & Reference
Practices & Lifestyle
Erectile Dysfunction — A Stepwise Optimization Protocol
Erectile dysfunction is more often a symptom of underlying physiology than a standalone problem. This protocol walks the evidence-based
L-Arginine
Category: Amino Acids Tags: Amino Acids, Nitric Oxide, Cardiovascular, Blood Pressure, Erectile Function Key Takeaways - Arginine is the primary substrate for endothelial nitric oxide synthase (eNOS) and a key driver of nitric oxide (NO)-mediated vasodilation — but citrulline achieves superior…
Maca (Lepidium meyenii): A Practical Guide
Overview Maca (Lepidium meyenii, Peruvian ginseng) is a cruciferous root vegetable native to the Andean plateau (3,500–4,500m elevation), where it has been cultivated for over 2,000 years for food and medicine. Its bioactive compounds include macamides (unique benzylated fatty acid amides)…
Nettle (Urtica dioica): A Practical Guide
Overview Stinging nettle (Urtica dioica) is a perennial flowering plant whose leaves, root, and seeds each have distinct pharmacological properties and evidence bases. Nettle leaf is used primarily for allergic rhinitis and anti-inflammatory applications; nettle root is studied for benign…
Panax Ginseng: A Practical Guide
At a Glance Panax ginseng (Asian or Korean ginseng) is one of the most extensively studied herbal adaptogens in the world, with a clinical trial database spanning cognitive function, fatigue, physical performance, immune modulation, and erectile dysfunction. Its active compounds — ginsenosides…
Tongkat Ali vs Fadogia Agrestis
Tongkat Ali (Eurycoma longifolia) and Fadogia agrestis are the two herbs that have dominated the men's testosterone-supplement conversation since approximately 2020. The pairing was popularized in optimization-medicine influencer content and has…
Tribulus Terrestris: A Practical Guide
Overview Tribulus terrestris (puncture vine, gokshura) is a flowering plant found worldwide in arid climates, used in both Ayurvedic and traditional Chinese medicine as an aphrodisiac, libido tonic, and general vitality herb. Its primary bioactive compounds are steroidal saponins—predominantly…
Yohimbine
Yohimbine is an indole alkaloid from the bark of the Pausinystalia yohimbe tree, used as a traditional aphrodisiac in West African medicine and prescribed for erectile dysfunction in the U.S. and Europe before sildenafil became available in 1998.…