AUTHOR
Emerging research: a 2026 combined analysis of randomized trials shows retatrutide moves blood pressure and cholesterol numbers — not just weight. Still not approved.
07 Sep 2026
N-acetylcysteine is an FDA-approved antidote for acetaminophen overdose; randomized trials leave most over-the-counter capsule wellness claims weakly supported or null.
07 Sep 2026
Methylene blue for oral use is a real drug, not a benign supplement. One small acute imaging study (Rodriguez 2016, n=26, 2 mg/kg) drives the cognitive claim. The Alzheimer's tau story is about a different molecule (LMTX). Serotonin syndrome risk with SSRIs, SNRIs, MAOIs is FDA-warned.
23 Jul 2026
Boron for men's health — the entire optimization case rests on one small pre-post study in eight men (Naghii 2011). No proper RCT replication exists. Safety margin at 3–10 mg/day is generous (adult UL 20 mg/day). Defensible as a low-cost hedge; not a testosterone move.
23 Jul 2026
Per 1,000 asymptomatic adults screened with WB-MRI: ~950 abnormal findings, ~15-20 cancers, ~30% trigger workup. Zero RCT mortality evidence. ACR does not recommend for average-risk adults. Vanguard's read on Prenuvo, Ezra, Q Bio.
19 Jul 2026
The NHS-Galleri trial missed its primary endpoint at ASCO 2026. High specificity (~99.6%) and PPV (52-62%), modest sensitivity (~30-40% all cancers), zero mortality data. $949 cash pay. No FDA approval as screening. Vanguard's read on the largest multi-cancer detection trial to date.
19 Jul 2026
Two lists — the Optimization List (12 non-negotiable tests before starting hormone, cardiovascular, or metabolic optimization) and the Vanguard List (25 total tests including 13 deep-dive add-ons). Tiered by evidence, honestly.
19 Jul 2026
Overview Tadalafil is a long-acting phosphodiesterase type 5 (PDE5) inhibitor — the same drug class as sildenafil, distinguished by a
07 Jul 2026
Losartan (Cozaar, first FDA-approved 1995) is the prototype angiotensin II receptor blocker. It shares the class-level mechanism (selective AT1 receptor blockade), core indications (hypertension, diabetic nephropathy, heart failure, cardiovascular…
05 Jul 2026
The short version "Fish oil for your heart" is largely oversold, because the capsule in most cabinets is
30 Jun 2026
Glucosamine and chondroitin sulfate are naturally occurring compounds found in healthy cartilage. Glucosamine is an amino sugar used by the body in glycosaminoglycan and proteoglycan synthesis; chondroitin sulfate is a long-chain sulfated…
23 Jun 2026
Cartalax (Ala-Glu-Asp, AED tripeptide) is one of approximately fifteen short-peptide bioregulators developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology beginning in the 1970s. The Khavinson…
12 Jun 2026
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