Practices & Lifestyle
5-HTP: A Practical Guide
At a Glance 5-Hydroxytryptophan (5-HTP) is the direct metabolic precursor to serotonin and melatonin, extracted from the seeds of Griffonia simplicifolia. Unlike tryptophan (which requires conversion to 5-HTP before becoming serotonin), 5-HTP crosses the blood-brain barrier efficiently and…
Alpha-GPC — Bioavailable Choline for Cognition and Performance
At a Glance Alpha-GPC (alpha-glycerophosphocholine) is one of the most bioavailable and best-studied oral choline precursors for supporting acetylcholine synthesis in the brain. It is used clinically in Europe for cognitive decline and post-stroke rehabilitation, and is widely used in the…
Ashwagandha: A Practical Guide
At a Glance Ashwagandha (Withania somnifera) is one of the most extensively studied adaptogenic botanicals, with a growing base of
Berberine: A Practical Guide
At a Glance Berberine is an isoquinoline alkaloid found in several medicinal plants — including Berberis aristata, Coptis chinensis, and Hydrastis canadensis — with one of the broadest and most replicated clinical trial bases of any botanical compound. Its primary mechanism is AMPK activation…
Collagen Peptides: A Practical Guide
At a Glance Collagen peptides (hydrolyzed collagen) are short-chain amino acid sequences derived from enzymatic hydrolysis of animal collagen,
CoQ10 / Ubiquinol: A Practical Guide
At a Glance Coenzyme Q10 (CoQ10, also known as ubiquinone) is a fat-soluble quinone that functions as a critical
Cordyceps Mushroom — Mitochondrial Support and Aerobic Performance
At a Glance Cordyceps is a genus of parasitic fungi with a documented history in Tibetan and Chinese medicine as a fatigue and performance compound. Two species dominate supplementation: Cordyceps sinensis (the wild, expensive, traditionally prized form) and Cordyceps militaris (the…
Creatine: A Practical Guide
At a Glance Creatine monohydrate is the most extensively researched and consistently effective performance supplement in sports science, with over
Curcumin: A Practical Guide
At a Glance Curcumin is the principal bioactive polyphenol in turmeric (Curcuma longa), responsible for its characteristic yellow color and
Lion's Mane Mushroom — NGF, Cognition, and Neuroprotection
At a Glance Lion's Mane (Hericium erinaceus) is a culinary and medicinal mushroom with one of the most
Magnesium: A Practical Guide
At a Glance Magnesium is an essential mineral and cofactor in over 300 enzymatic reactions, including ATP synthesis, DNA replication
Myo-Inositol: A Practical Guide
At a Glance Myo-inositol is a naturally occurring sugar alcohol and a structural component of cell membrane phospholipids, serving as a key intracellular second messenger in insulin, FSH, and TSH signaling cascades. Its most robust clinical evidence is in polycystic ovary syndrome (PCOS)…
NMN: A Practical Guide
At a Glance Nicotinamide mononucleotide (NMN) is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme central to cellular energy metabolism, DNA repair, and sirtuin-mediated longevity signaling. NAD+ levels decline with age — approximately 50% from young adulthood to…
Omega-3 & Fish Oil: A Practical Guide
At a Glance Omega-3 fatty acids — specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) — are long-chain polyunsaturated fatty acids found primarily in marine sources, with the most extensive evidence base of any dietary supplement for cardiovascular health. Triglyceride…
Panax Ginseng: A Practical Guide
At a Glance Panax ginseng (Asian or Korean ginseng) is one of the most extensively studied herbal adaptogens in the world, with a clinical trial database spanning cognitive function, fatigue, physical performance, immune modulation, and erectile dysfunction. Its active compounds — ginsenosides…
Rapamycin (Sirolimus) — The mTOR Longevity Case
At a Glance Rapamycin (sirolimus) is an FDA-approved mTOR inhibitor with some of the most compelling preclinical longevity evidence of any existing compound — it is the best-studied mTOR inhibitor for lifespan extension in multiple mammalian models, including trials where treatment began late…
Reishi Mushroom — Immune Longevity and Adaptogenic Support
At a Glance Reishi (Ganoderma lucidum) is one of the most extensively researched medicinal mushrooms in traditional and modern pharmacology, used in East Asian medicine for over 2,000 years. Its primary bioactives — triterpenoids and beta-glucan polysaccharides — deliver a well-documented…
Resveratrol: A Practical Guide
At a Glance Resveratrol is a stilbenoid polyphenol found primarily in grape skin, red wine, and Japanese knotweed (the primary
Rhodiola Rosea — Adaptogenic Stress and Cognitive Performance
At a Glance Rhodiola rosea is a Scandinavian and Central Asian adaptogenic herb with one of the strongest clinical evidence bases among botanical adaptogens. Its primary bioactives — rosavins and salidroside — have been studied in over 36 human clinical trials covering stress, fatigue…
Saffron: A Practical Guide
At a Glance Saffron (Crocus sativus) has accumulated one of the stronger human clinical trial databases of any botanical for mood support — multiple RCTs have demonstrated antidepressant effects in mild-to-moderate depression, including direct comparisons to fluoxetine and imipramine showing…
Shilajit: A Practical Guide
At a Glance Shilajit is a mineral-rich resin that forms over centuries from the decomposition of plant matter in
Turkey Tail Mushroom: A Practical Guide
At a Glance Turkey Tail (Trametes versicolor) is among the most clinically researched medicinal mushrooms, distinguished by two well-characterized immunomodulatory polysaccharides: polysaccharide-K (PSK, also known as Krestin) and polysaccharide-peptide (PSP). PSK has been an approved cancer…
Vitamin D3 + K2: A Practical Guide
At a Glance Vitamin D3 (cholecalciferol) is a fat-soluble prohormone produced in skin upon UVB exposure and found in
Zinc: A Practical Guide
At a Glance Zinc is an essential trace mineral and structural cofactor in over 300 enzymes, playing fundamental roles in