At a Glance Rapamycin (sirolimus) is an FDA-approved mTOR inhibitor with some of the most compelling preclinical longevity evidence of any existing compound — it is the best-studied mTOR inhibitor for lifespan extension in multiple mammalian models, including trials where treatment began late…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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