Compounds & Therapies
5-Amino-1MQ — NNMT Inhibitor
5-Amino-1-methylquinolinium iodide (5-amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. Two metabolic problems flow from…
Bempedoic Acid (Nexletol)
Bempedoic acid is the first ATP-citrate lyase inhibitor approved for clinical use, and the first oral non-statin to demonstrate cardiovascular outcome benefit in a large randomized trial. It lowers LDL cholesterol by inhibiting ATP-citrate lyase…
Inclisiran (Leqvio)
Inclisiran is a small interfering RNA (siRNA) therapeutic that silences the production of PCSK9 in the liver. Functionally, the result is the same as the monoclonal antibody PCSK9 inhibitors (evolocumab, alirocumab): more LDL receptors on hepatocyte…
Practices & Lifestyle
ACE Inhibitors (Angiotensin-Converting Enzyme Inhibitors): A Practical Guide
ARBs (Angiotensin Receptor Blockers): A Practical Guide
Beta-Blockers and Aging: A Practical Guide
Dasatinib + Quercetin (D+Q Senolytic Combination): A Practical Guide
Glutathione (GSH): A Practical Guide
Metformin: A Practical Guide
MitoQ (Mitoquinone): A Practical Guide
Navitoclax (ABT-263): A Practical Guide
PCSK9 Inhibitors: A Practical Guide