Monograph
Inclisiran (Leqvio)
Inclisiran is a small interfering RNA (siRNA) therapeutic that silences the production of PCSK9 in the liver. Functionally, the result is the same as the monoclonal antibody PCSK9 inhibitors (evolocumab, alirocumab): more LDL receptors on hepatocyte…
By Kristopher Crawford
·
29 May 2026
·
4 min read
Inclisiran is a small interfering RNA (siRNA) therapeutic that silences the production of PCSK9 in the liver. Functionally, the result is the same as the monoclonal antibody PCSK9 inhibitors (evolocumab, alirocumab): more LDL receptors on hepatocyte…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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