Overview PCSK9 inhibitors are a class of biologic agents (monoclonal antibodies) that block proprotein convertase subtilisin/kexin type 9 (PCSK9) — a circulating protein that promotes degradation of LDL receptors (LDLRs) on the surface of hepatocytes. By inhibiting PCSK9, these drugs prevent…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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