Testing & Tracking
Compounds & Therapies
Acarbose
Alpha-glucosidase inhibitor: approved for type 2 diabetes, longevity potential in animal models
Alpha-Ketoglutarate (AKG)
A metabolic intermediate supporting cellular energy production and muscle protein synthesis
Anastrozole
Aromatase Inhibitor for Selective Estrogen Reduction
AOD-9604
Failed Drug Candidate With Misleading GRAS Status
Apigenin
Chamomile-derived flavonoid with CD38 inhibition and NAD+ modulation potential
ARA-290 (Cibinetide)
Innate Repair Receptor Agonist in Phase 2 Development
Ashwagandha
A traditional adaptogenic herb with clinical evidence for stress resilience and cognitive function
Astaxanthin
A powerful carotenoid antioxidant supporting eye health, athletic recovery, and cardiovascular function
B-Complex Vitamins
Essential water-soluble vitamins supporting energy metabolism, neurological function, and stress resilience
Berberine
A plant alkaloid with emerging evidence for metabolic and cardiovascular support, requiring clinical context
Boron
An essential trace mineral supporting bone health, hormonal balance, and cognitive function
BPC-157
Emerging Peptide for Tissue Repair Research
Citrulline (L-Citrulline)
Amino acid nitric oxide precursor for vascular function and athletic performance
CJC-1295
Long-Acting GHRH Analog for GH Secretion Research
Collagen
Hydrolyzed peptides supporting skin, joint, and connective tissue health through targeted amino acid delivery
Colostrum (Bovine)
Bovine first-milk concentrate for immune support and gut barrier health
CoQ10 (Ubiquinone) & Ubiquinol
A mitochondrial cofactor supporting energy production, cardiovascular health, and statin-related outcomes
Creatine Monohydrate
The gold standard for muscle energy and strength, backed by decades of research and approved globally
Curcumin & Turmeric Extract
A powerful polyphenol supporting inflammatory control and antioxidant defense, with bioavailability optimization required
DHEA (Dehydroepiandrosterone)
The Foundational Prohormone for Hormonal Precursors
Dihexa
Angiotensin IV Analog With No Human Safety Data
DIM (Diindolylmethane)
Cruciferous phytochemical for estrogen metabolism support and hormonal balance
Dutasteride
5-alpha reductase inhibitor: approved for BPH, off-label for androgenetic alopecia
Enclomiphene
The Active Isomer of Clomiphene for Testicular Function Preservation
Epitalon
Unproven Telomerase Activator From Russia
Fadogia Agrestis
A traditional West African plant with limited regulatory guidance and concerning preclinical safety signals requiring clinical oversight
Finasteride
5-Alpha Reductase Inhibition for Prostate Health and Hair Preservation
Fisetin
Strawberry-derived flavonoid senolytic with Mayo Clinic clinical trial support
Fish Oil (Omega-3 Fatty Acids)
Essential omega-3 fatty acids supporting cardiovascular, neurological, and inflammatory health globally
GF9 (Amino Acid Blend)
A proprietary amino acid formulation marketed for growth hormone support with limited independent validation
GHK-Cu (Copper Peptide)
Cosmetic Peptide With Topical Benefits and Injectable Research Status
Glycine
The simplest amino acid supporting sleep quality, collagen synthesis, and neurological function
Gonadotropin Guide
HCG (Human Chorionic Gonadotropin)
HMB (Beta-Hydroxy Beta-Methylbutyrate)
A leucine metabolite supporting muscle protein synthesis and exercise recovery with solid clinical evidence
Hormonal Guide
Cabergoline
IGF-LR3 (Insulin-Like Growth Factor-1 Long Arg3)
Potent Modified IGF-1 With Extreme Abuse Potential
Immunomodulation Guide
Low Dose Naltrexone (LDN)
Inulin
A prebiotic fiber supporting gut microbiota, digestive health, and metabolic markers
Ipamorelin
Selective GH Secretagogue for Research Use
Kisspeptin
Investigational Reproductive Peptide in Active Research
KPV (Lysine-Proline-Valine)
Tripeptide Fragment With Zero Human Evidence
L-Theanine
An amino acid supporting relaxed focus, mental clarity, and stress resilience without sedation
Leucine
An essential branched-chain amino acid crucial for muscle protein synthesis and metabolic signaling
Levothyroxine (T4)
The Standard Treatment for Thyroid Hormone Replacement
LL-37
Human Cathelicidin Antimicrobial Peptide (Preclinical Only)
Low-Dose Lithium
Neuroprotective at 5-20mg daily; regulatory ambiguity between pharmaceutical lithium and supplements
Lysine
An essential amino acid supporting collagen synthesis, immune function, and herpes simplex virus management
Magnesium
An essential mineral supporting energy production, relaxation, and cardiovascular health across multiple forms
Melatonin
A natural sleep hormone supporting circadian rhythm regulation and sleep quality with major global regulatory divergence
Metformin
The Metabolic Workhorse for Glucose Control and Longevity
Methylene Blue
Antioxidant with cognitive enhancement potential, serotonin syndrome risk critical
Minoxidil
FDA-approved OTC topical for hair loss; oral off-label but increasingly prescribed
Modafinil
Wakefulness promotion with schedule IV controls
MOTS-c (Mitochondrial-Derived Peptide)
Preclinical Mitochondrial Peptide With Theoretical Metabolic Benefits
NAC (N-Acetyl Cysteine)
Cellular antioxidant and glutathione precursor for robust defense
NAD+ Precursors (NMN/NR)
Cellular energy currency and sirtuin activator with evolving regulatory status
Neprinol
Proprietary systemic enzyme blend for proteolytic and fibrinolytic support
Oxytocin
The Bonding and Trust Hormone for Social and Intimate Function
Pentadecanoic Acid (C15:0)
Odd-chain saturated fatty acid for metabolic flexibility and cellular signaling
Pregnenolone
The Original Steroid Hormone Precursor
Probiotics (General)
Live beneficial bacteria for microbiome support and digestive wellness
PT-141 (Bremelanotide)
FDA-Approved Melanocortin Agonist (Women Only)
Pterostilbene
Methylated resveratrol analog with superior bioavailability and sirtuin activation
Quercetin
Bioflavonoid antioxidant and senolytic candidate with emerging longevity research
Resveratrol
Grape-derived stilbene and sirtuin activator with mixed clinical outcomes
Saw Palmetto
Traditional herbal extract with EMA monograph for prostate and urinary health
Selank
Russian-Approved Anxiolytic Peptide (Tuftsin Analog)
Selenium
Essential trace mineral with narrow therapeutic window and anti-cancer implications
Semax
Russian-Approved Neuroprotective Peptide (ACTH Analog)
Sermorelin
FDA-Approved GHRH Analog (Discontinued Commercially, Available via Compounding)
SGLT2 Inhibitors
Approved for type 2 diabetes, heart failure, and chronic kidney disease; off-label longevity and cardiometabolic optimization
Sildenafil (Viagra)
The Original Phosphodiesterase-5 Inhibitor for Erectile Function
Spermidine
Polyamine autophagy inducer with longevity research implications
SS-31 (Elamipretide)
Investigational Mitochondrial Protective Peptide in Active Development
Statins
Most prescribed drugs globally; approved for primary and secondary cardiovascular prevention
Sulforaphane (Broccoli Extract)
Cruciferous phytochemical with potent anti-cancer and detoxification support
Tadalafil (Cialis)
The Long-Acting Phosphodiesterase-5 Inhibitor for Erectile Function and Hemodynamics
Taurine
Conditionally essential amino acid for cardiac, neurological, and metabolic support
TB-500 (Thymosin Beta-4)
Actin-Binding Peptide Under Scrutiny
Telmisartan
ARB with unique PPAR-gamma activation; off-label optimization use emerging
Tesamorelin
FDA-Approved GHRH Analog for HIV-Associated Lipodystrophy
Testosterone
The Gold Standard in Male Hormone Optimization
Thymosin Alpha-1
Approved in 35+ Countries (Except US, EU, UK, Australia, Canada)
Thyroid T3/Combination (NDT)
Direct T3 or Natural Desiccated Thyroid for Patients Unresponsive to T4 Alone
TMG/Betaine (Trimethylglycine)
Methyl donor for homocysteine reduction and cellular methylation support
Tongkat Ali (Eurycoma longifolia)
Traditional Southeast Asian herbal root extract for testosterone and vitality support
Urolithin A
Postbiotic mitophagy activator for cellular quality control and longevity
Ursolic Acid
Pentacyclic triterpenoid from apple peel with emerging longevity potential
VIP (Vasoactive Intestinal Peptide)
Endogenous Neuropeptide With Limited Clinical Evidence for CIRS
Vitamin C (Oral)
Antioxidant and collagen synthesis cofactor for immunity and connective tissue health
Vitamin D3
Secosteroid hormone precursor for skeletal, immune, and metabolic health
Vitamin K2 (MK-7)
Menaquinone-7 for bone mineralization and vascular health with critical warfarin interactions
Zinc
Essential trace mineral for immune function, protein synthesis, and cellular health
Procedures & Modalities
Azelaic Acid
Azelaic acid is available in FDA-approved prescription formulations: Finacea 15% (for mild to moderate rosacea) and Azelex 20% (for mild to moderate acne vulgaris).
Bakuchiol
Plant-derived cosmetic; not drug-regulated; retinol alternative marketed globally
Blood Flow Restriction Training (BFR)
Unregulated training modality; emerging evidence for strength and hypertrophy at low loads
Breathwork & Breathing Techniques
Non-regulated practice; device-free; evidence for stress reduction and parasympathetic activation
Chemical Peels (AHAs/BHAs)
OTC superficial peels are cosmetics; professional/medical peels are regulated procedures
Cold Water Immersion (Cold Plunge)
Unregulated practice; emerging evidence for immune function and stress resilience; cardiovascular precautions necessary
Compression Therapy
Device-regulated; clinical use for venous insufficiency; athletic recovery use emerging and less regulated
Dry Needling (Intramuscular Stimulation)
Practitioner-regulated; acupuncture-like but targeting muscle trigger points; emerging evidence for pain
Electrical Muscle Stimulation (EMS)
Device-regulated; FDA-cleared for muscle stimulation; consumer devices vary in quality and efficacy
Float Tank Therapy (Sensory Deprivation)
Unregulated wellness practice; no device approval; emerging evidence for relaxation and stress reduction
Grounding/Earthing
Unregulated practice; direct earth contact or grounding devices; emerging evidence for inflammation and sleep
Hot Tub & Hydrotherapy
Unregulated practice; evidence for muscle relaxation and stress reduction; hygiene standards vary
Hyaluronic Acid
Topical cosmetic (unregulated); injectable fillers FDA-cleared as medical devices (not drug-approved)
Hyperbaric Oxygen Therapy (HBOT)
Device-regulated; FDA-approved for specific medical indications; off-label wellness use emerging
IV Nutrient Therapy (Vitamin Infusions)
Unregulated practice when used off-label; bypasses oral bioavailability limits; evidence limited
Massage Therapy & Manual Therapy
Licensed profession in many jurisdictions; no medical device; evidence for muscle tension and stress reduction
Microneedling
Device-regulated procedure; professional devices cleared; home devices <0.5mm less regulated
Neuromodulation Modality Guide
Neurofeedback
Niacinamide (Topical)
Well-tolerated cosmetic ingredient; anti-inflammatory and barrier support
Ozone Therapy
Unregulated practice; oxidative stress mechanism; lacks robust clinical evidence; safety concerns
PEMF Therapy (Pulsed Electromagnetic Field)
Device status varies; some FDA-cleared for specific indications; off-label wellness use largely unregulated
PRP for Skin & Hair
Device-regulated autologous procedure; PRP device FDA-cleared but aesthetic applications investigational
PRP Injections (Joint & Soft Tissue)
Device-regulated centrifuge; procedure unregulated; emerging evidence for joint pain and tendinopathy
Red Light (Low-Level Laser) Therapy
Device-regulated; FDA-cleared for pain and wound healing; off-label anti-aging and cognitive use emerging
Sauna (Dry & Steam)
Unregulated wellness practice; evidence for cardiovascular and heat stress adaptation benefits
Shockwave Therapy (ESWT)
Device-regulated; FDA-approved (PMA) for plantar fasciitis and lateral epicondylitis; emerging use for vascularity and ED
Sunscreen & UV Protection
FDA OTC drug monograph; EU offers wider filter options; US lags in approved filters
Topical Vitamin C
Antioxidant cosmetic ingredient; not drug-regulated globally, quality varies enormously
Tretinoin (Retinoids)
Gold standard retinoid for photoaging and acne; prescription-only globally
Whole Body Cryotherapy (WBC)
Device-regulated; emerging evidence for recovery; safety concerns with extreme cold; athletic use growing
Protocols & Reference
Cardiovascular Optimization Protocol
Multi-level cardiovascular health strategy combining lifestyle, biomarkers, and evidence-based medications
Coagulation Risks of Supplements -- Safety Series--FOR ALL MEMBERS
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Cognitive Performance & Brain Health Protocol: From Daily Focus to Long-Term Neuroprotection
Protocol Guide Series | April 2026 | FOR VANGUARD MEMBERS ONLY — Cognitive Performance & Brain Health Protocol: From Daily Focus to Long-Term Neuroprotection
CRITICAL SAFETY INFORMATION:Safety Reference Series / FOR ALL MEMBERS —
Legal, Regulatory & General Safety Precautions: What Every Member Must Understand
Gut Health & Immune Optimization Protocol
Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY — Gut Health & Immune Optimization Protocol
Hair Loss Prevention & Growth Protocol
Evidence-based multi-compound protocol for androgenetic alopecia addressing DHT, micro-inflammation, and hair growth signaling
Hormonal Cautions -- Safety Series
Safety Reference Series — April 2026 • FOR ALL MEMBERS
Nootropic Stack Guide
Rational multi-compound cognitive enhancement strategy balancing risk-benefit and individual variation
Peptide Stacking Protocol: Research-Based Combination Frameworks
Skin and Hair Optimization
Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY — Protocol Skinhairoptimization
Sleep Optimization Protocol
Evidence-based multi-compound and behavioral strategy for sleep quality and duration
Stress, Recovery & Performance Protocol: A Systems Approach | FOR VANGUARD MEMBERS ONLY
Protocol Guide Series — April 2026 | FOR VANGUARD MEMBERS ONLY
Supplement Interactions -- Safety Series -- ALL MEMBERS
Compound Interactions & Contraindications
Supplement-Medication Interaction Matrix
A Quick-Reference Safety Guide
Testosterone Optimization Protocol: A Complete Framework
Protocol Guide Series — Testosterone Optimization Protocol: A Complete Framework
VANGUARD OPTIMIZATION Protocol Guide Series METABOLIC & BODY COMPOSITION OPTIMIZATION PROTOCOL April 2026 | FOR VANGUARD MEMBERS ONLY
VANGUARD OPTIMIZATION / Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY
Longevity & Anti-Aging Protocol: Evidence-Based Healthspan Extension