Pterostilbene raised LDL cholesterol by 17.1 mg/dL in the best human RCT (Riche 2014, n=80, P=0.001). The sirtuin/longevity claim has not translated to demonstrated human clinical benefit. Vanguard's revised position: we do not recommend oral pterostilbene supplementation.
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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