AUTHOR
Specialized pro-resolving mediators (SPMs) are a family of bioactive lipid mediators derived enzymatically from omega-3 fatty acids — primarily EPA and DHA. They include the resolvins (E-series from EPA, D-series from DHA), protectins (from DHA),…
30 May 2026
Niacin (nicotinic acid, vitamin B3) at pharmacologic doses (typically 1,500-2,000 mg/day) has substantial effects on the lipid profile — raising HDL by 15-35%, lowering triglycerides by 20-50%, lowering LDL by 5-25%, and lowering lipoprotein(a) by…
30 May 2026
Nattokinase is a serine protease enzyme extracted from natto, the traditional Japanese fermented soybean food. It was discovered and characterized by Sumi and colleagues in 1987 as the active fibrinolytic constituent in natto, with strong in vitro…
30 May 2026
The DUTCH test (Dried Urine Test for Comprehensive Hormones, Precision Analytical) measures a panel of steroid hormones and their metabolites from dried urine spots collected at specified times across a 24-hour period. The test has become a popular…
30 May 2026
Thyroid evaluation in U.S. clinical practice traditionally starts with thyroid-stimulating hormone (TSH) — the most sensitive marker of thyroid status in adults with intact hypothalamic-pituitary-thyroid axis function. Free T4, free T3, reverse T3,…
30 May 2026
Small intestinal bacterial overgrowth (SIBO) describes an excessive concentration of bacteria in the small intestine, traditionally defined as ≥10⁵ colony-forming units per mL on small bowel aspirate. The condition has been increasingly diagnosed…
30 May 2026
Wrist-worn and finger-worn sleep tracking has become ubiquitous in the optimization community. Two distinct categories of devices are commonly confused: FDA-cleared home sleep apnea test (HSAT) devices like WatchPAT (Itamar Medical), and consumer…
30 May 2026
Sleep-disordered breathing — primarily obstructive sleep apnea (OSA) — is one of the most common, most underdiagnosed, and most consequential conditions in adult medicine. Untreated moderate-to-severe OSA is associated with hypertension, atrial…
30 May 2026
Tongkat Ali (Eurycoma longifolia) and Fadogia agrestis are the two herbs that have dominated the men's testosterone-supplement conversation since approximately 2020. The pairing was popularized in optimization-medicine influencer content and has…
30 May 2026
Modern lipid management has four major pharmacological pillars: statins (the dominant first-line therapy), PCSK9 inhibitor monoclonal antibodies (evolocumab and alirocumab, the most potent LDL-lowering option), bempedoic acid (the newer non-statin…
30 May 2026
Rapamycin (sirolimus) and metformin are the two off-label drugs most often discussed in the longevity optimization conversation. Both have substantial preclinical evidence for healthspan or lifespan benefit, both have been the subject of ongoing…
30 May 2026
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme central to cellular energy metabolism, DNA repair, and sirtuin-mediated signaling involved in aging biology. Circulating and tissue NAD+ levels decline with age in animals and humans. Multiple…
30 May 2026
Bug report, content request, or general comment — we read everything.