Monograph
Specialized Pro-Resolving Mediators (SPMs)
Specialized pro-resolving mediators (SPMs) are a family of bioactive lipid mediators derived enzymatically from omega-3 fatty acids — primarily EPA and DHA. They include the resolvins (E-series from EPA, D-series from DHA), protectins (from DHA),…
By Kristopher Crawford
·
30 May 2026
·
5 min read
Specialized pro-resolving mediators (SPMs) are a family of bioactive lipid mediators derived enzymatically from omega-3 fatty acids — primarily EPA and DHA. They include the resolvins (E-series from EPA, D-series from DHA), protectins (from DHA),…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
MEMBERS
Read the full monograph
Members get every monograph in the library, the research assistant, and the stack tracker — with a 30-day money-back guarantee. Not ready? Start free with the Proven Supplements Starter Guide.