Sexual Health

Apomorphine for Erectile Dysfunction

Apomorphine is a non-selective dopamine receptor agonist with a long history in medicine — originally used as an emetic in poisoning treatment, more recently in Parkinson's disease management (subcutaneous Apokyn, sublingual Kynmobi). For erectile…

SSRIs — Long-Term Use and PSSD

Selective serotonin reuptake inhibitors (SSRIs) — fluoxetine, sertraline, citalopram, escitalopram, paroxetine, fluvoxamine — and the closely related SNRIs (venlafaxine, duloxetine) are among the most-prescribed medication classes in modern…

Trimix Injections

Trimix is a compounded intracavernosal injection containing three vasoactive drugs: alprostadil (a prostaglandin E1 analog), papaverine (a smooth-muscle relaxant), and phentolamine (an alpha-adrenergic antagonist). Self-administered by…

Pelvic Floor Physical Therapy for Men

Pelvic floor physical therapy (PFPT) for men is one of the most under-prescribed, under-recognized evidence-based interventions in men's health. The male pelvic floor — including the levator ani, coccygeus, and supporting muscle groups — is integral…

Erectile Dysfunction — A Stepwise Optimization Protocol

Yohimbine

Yohimbine is an indole alkaloid from the bark of the Pausinystalia yohimbe tree, used as a traditional aphrodisiac in West African medicine and prescribed for erectile dysfunction in the U.S. and Europe before sildenafil became available in 1998.…