Protocols

Bloodwork Interpretation Guide

Educational guide for understanding blood work, reference ranges, and optimization targets

Macular Protection Stack (AREDS2)

The Age-Related Eye Disease Study (AREDS) and its successor AREDS2 are among the most rigorously conducted nutritional intervention trials in modern medicine. Funded by the National Eye Institute and conducted over more than two decades, the trials…

Strength Training for Longevity

Skeletal muscle is increasingly recognized in the longevity literature as a metabolic and endocrine organ — a glucose disposal sink, an endocrine signaling source (myokines), a reserve for the metabolic challenges of acute illness and recovery, and…

VO2max Maximization Protocols

Maximal oxygen uptake (VO₂max) is the single most predictive fitness metric for all-cause mortality across multiple population studies — more predictive than smoking, hypertension, diabetes, or any other commonly measured risk factor. Each one-MET…

Acne: A Practical Protocol

Cardiovascular Optimization Protocol

Multi-level cardiovascular health strategy combining lifestyle, biomarkers, and evidence-based medications

Carnivore Diet — Sober Review

The carnivore diet — exclusive or near-exclusive consumption of animal products, eliminating all plants — has grown from a fringe practice associated with Shawn Baker and Mikhaila Peterson around 2018 into a major cultural movement with millions of…

Cognitive Performance & Brain Health Protocol: From Daily Focus to Long-Term Neuroprotection

Protocol Guide Series | April 2026 | FOR VANGUARD MEMBERS ONLY — Cognitive Performance & Brain Health Protocol: From Daily Focus to Long-Term Neuroprotection

Fasting-Mimicking Diet (Prolon)

The fasting-mimicking diet (FMD) is a 5-day, low-calorie, low-protein, low-carbohydrate dietary protocol developed by Valter Longo's group at USC and commercialized as the Prolon program (L-Nutra). The protocol provides about 4,600 kJ (\(~1,100\)…

Gut Health & Immune Optimization Protocol

Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY — Gut Health & Immune Optimization Protocol

Hair Loss Prevention & Growth Protocol

Evidence-based multi-compound protocol for androgenetic alopecia addressing DHT, micro-inflammation, and hair growth signaling

Nootropic Stack Guide

Rational multi-compound cognitive enhancement strategy balancing risk-benefit and individual variation

Peptide Stacking Protocol: Research-Based Combination Frameworks

Prolonged Fasting (3, 5, 7 Day)

Prolonged water-only or near-water-only fasting — typically 3, 5, or 7 days — has emerged from a niche longevity practice into a recurring feature of the men's optimization conversation. The mechanistic case is interesting: prolonged fasting drives…

Skin and Hair Optimization

Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY — Protocol Skinhairoptimization

Sleep Optimization Protocol

Evidence-based multi-compound and behavioral strategy for sleep quality and duration

Stress, Recovery & Performance Protocol: A Systems Approach | FOR VANGUARD MEMBERS ONLY

Protocol Guide Series — April 2026 | FOR VANGUARD MEMBERS ONLY

Testosterone Optimization Protocol: A Complete Framework

Protocol Guide Series — Testosterone Optimization Protocol: A Complete Framework

Time-Restricted Eating

Time-restricted eating (TRE) is the practice of confining all daily caloric intake to a defined window — most commonly 8 hours (16:8), 10 hours (14:10), 6 hours (18:6), or one meal per day (23:1, OMAD). The intervention has exploded in cultural…

VANGUARD OPTIMIZATION Protocol Guide Series METABOLIC & BODY COMPOSITION OPTIMIZATION PROTOCOL April 2026 | FOR VANGUARD MEMBERS ONLY

VANGUARD OPTIMIZATION / Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY

Longevity & Anti-Aging Protocol: Evidence-Based Healthspan Extension