Testing & Tracking
Compounds & Therapies
Procedures & Modalities
Strength Training for Longevity
Skeletal muscle is increasingly recognized in the longevity literature as a metabolic and endocrine organ — a glucose disposal sink, an endocrine signaling source (myokines), a reserve for the metabolic challenges of acute illness and recovery, and…
VO2max Maximization Protocols
Maximal oxygen uptake (VO₂max) is the single most predictive fitness metric for all-cause mortality across multiple population studies — more predictive than smoking, hypertension, diabetes, or any other commonly measured risk factor. Each one-MET…
Protocols & Reference
Acne: A Practical Protocol
At a Glance Acne vulgaris is the most common skin condition globally, affecting up to 85% of individuals at some point in their lives and persisting into adulthood in a significant portion of cases. Effective treatment requires matching intervention to acne type — comedonal, inflammatory, or…
Cardiovascular Optimization Protocol
Multi-level cardiovascular health strategy combining lifestyle, biomarkers, and evidence-based medications
Carnivore Diet — Sober Review
The carnivore diet — exclusive or near-exclusive consumption of animal products, eliminating all plants — has grown from a fringe practice associated with Shawn Baker and Mikhaila Peterson around 2018 into a major cultural movement with millions of…
Cognitive Performance & Brain Health Protocol: From Daily Focus to Long-Term Neuroprotection
Protocol Guide Series | April 2026 | FOR VANGUARD MEMBERS ONLY — Cognitive Performance & Brain Health Protocol: From Daily Focus to Long-Term Neuroprotection
Fasting-Mimicking Diet (Prolon)
The fasting-mimicking diet (FMD) is a 5-day, low-calorie, low-protein, low-carbohydrate dietary protocol developed by Valter Longo's group at USC and commercialized as the Prolon program (L-Nutra). The protocol provides about 4,600 kJ (\(~1,100\)…
Gut Health & Immune Optimization Protocol
Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY — Gut Health & Immune Optimization Protocol
Hair Loss Prevention & Growth Protocol
Evidence-based multi-compound protocol for androgenetic alopecia addressing DHT, micro-inflammation, and hair growth signaling
Nootropic Stack Guide
Rational multi-compound cognitive enhancement strategy balancing risk-benefit and individual variation
Peptide Stacking Protocol: Research-Based Combination Frameworks
TABLE OF CONTENTS 1. Protocol Overview & Critical Disclaimers 2. Peptide Categories & Functional Mechanisms 3. Goal-Based Stacking Frameworks 4. Critical Stacking Rules & Safety Principles 5. Reconstitution, Storage & Administration 6. Monitoring Framework & Baseline Requirements 7.
Prolonged Fasting (3, 5, 7 Day)
Prolonged water-only or near-water-only fasting — typically 3, 5, or 7 days — has emerged from a niche longevity practice into a recurring feature of the men's optimization conversation. The mechanistic case is interesting: prolonged fasting drives…
Skin and Hair Optimization
Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY — Protocol Skinhairoptimization
Sleep Optimization Protocol
Evidence-based multi-compound and behavioral strategy for sleep quality and duration
Stress, Recovery & Performance Protocol: A Systems Approach | FOR VANGUARD MEMBERS ONLY
Protocol Guide Series — April 2026 | FOR VANGUARD MEMBERS ONLY
Testosterone Optimization Protocol: A Complete Framework
Protocol Guide Series — Testosterone Optimization Protocol: A Complete Framework
Time-Restricted Eating
Time-restricted eating (TRE) is the practice of confining all daily caloric intake to a defined window — most commonly 8 hours (16:8), 10 hours (14:10), 6 hours (18:6), or one meal per day (23:1, OMAD). The intervention has exploded in cultural…
VANGUARD OPTIMIZATION Protocol Guide Series METABOLIC & BODY COMPOSITION OPTIMIZATION PROTOCOL April 2026 | FOR VANGUARD MEMBERS ONLY
1. PROTOCOL OVERVIEW Why Metabolic Health is Foundational Metabolic health—the efficient processing of glucose, fats, and amino acids; appropriate inflammatory tone; healthy body composition; and appropriate energy expenditure—forms the foundation upon which all other aspects of health depend.
VANGUARD OPTIMIZATION / Protocol Guide Series / April 2026 / FOR VANGUARD MEMBERS ONLY
Longevity & Anti-Aging Protocol: Evidence-Based Healthspan Extension