Longevity

Epigenetic Age Clocks — TruDiagnostic vs DunedinPACE vs GlycanAge

"Biological age" — as distinct from chronological age — has become one of the most-marketed concepts in the longevity consumer space. The underlying science is real and increasingly substantial: it is now well-established that certain DNA…

ALCAR / L-Carnitine: A Practical Guide

Alpha-Lipoic Acid: A Practical Guide

Losartan — The Uricosuric ARB with a Marfan and TGF-β Story

Losartan (Cozaar, first FDA-approved 1995) is the prototype angiotensin II receptor blocker. It shares the class-level mechanism (selective AT1 receptor blockade), core indications (hypertension, diabetic nephropathy, heart failure, cardiovascular…

Phosphatidylserine: A Practical Guide

Pinealon

Pinealon (Glu-Asp-Arg) is a synthetic tripeptide developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. It is part of the broader Khavinson 'short peptide' bioregulator program, which has…

Adapalene: A Practical Guide

Ceramides & Barrier Repair: A Practical Guide

Retinaldehyde: A Practical Guide

Mid-Life Cognitive Optimization — A Sober Protocol

NMN (Nicotinamide Mononucleotide): NAD+ Precursor Guide

NMN raises NAD+ levels in humans with solid mechanistic rationale and early clinical data. Updated September 2025: FDA confirmed NMN lawful as a dietary supplement, reversing a 2022 exclusion.

Rapamycin vs Metformin for Longevity

Rapamycin (sirolimus) and metformin are the two off-label drugs most often discussed in the longevity optimization conversation. Both have substantial preclinical evidence for healthspan or lifespan benefit, both have been the subject of ongoing…

Resveratrol: A Practical Guide

Zone 2 Training: A Practical Guide