THE VANGUARD BLOG
Physician-curated deep dives into the science of men's health optimization.
Skincare Guides
At a Glance Acne vulgaris is the most common skin condition globally, affecting up to 85% of individuals at some point in their lives and persisting into adulthood in a significant portion of cases. Effective treatment requires matching intervention to acne type — comedonal, inflammatory, or…
27 Apr 2026
Supplement Guides
At a Glance Ashwagandha (Withania somnifera) is one of the most extensively studied adaptogenic botanicals, with a growing base of
27 Apr 2026
Supplement Guides
At a Glance Berberine is an isoquinoline alkaloid found in several medicinal plants — including Berberis aristata, Coptis chinensis, and Hydrastis canadensis — with one of the broadest and most replicated clinical trial bases of any botanical compound. Its primary mechanism is AMPK activation…
27 Apr 2026
Supplement Guides
At a Glance Coenzyme Q10 (CoQ10, also known as ubiquinone) is a fat-soluble quinone that functions as a critical
27 Apr 2026
Supplement Guides
At a Glance Creatine monohydrate is the most extensively researched and consistently effective performance supplement in sports science, with over
27 Apr 2026
Supplement Guides
At a Glance Magnesium is an essential mineral and cofactor in over 300 enzymatic reactions, including ATP synthesis, DNA replication
27 Apr 2026
Supplement Guides
At a Glance Nicotinamide mononucleotide (NMN) is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme central to cellular energy metabolism, DNA repair, and sirtuin-mediated longevity signaling. NAD+ levels decline with age — approximately 50% from young adulthood to…
27 Apr 2026
Supplement Guides
At a Glance 5-Hydroxytryptophan (5-HTP) is the direct metabolic precursor to serotonin and melatonin, extracted from the seeds of Griffonia simplicifolia. Unlike tryptophan (which requires conversion to 5-HTP before becoming serotonin), 5-HTP crosses the blood-brain barrier efficiently and…
27 Apr 2026
Supplement Guides
At a Glance Myo-inositol is a naturally occurring sugar alcohol and a structural component of cell membrane phospholipids, serving as a key intracellular second messenger in insulin, FSH, and TSH signaling cascades. Its most robust clinical evidence is in polycystic ovary syndrome (PCOS)…
27 Apr 2026
Supplement Guides
At a Glance Panax ginseng (Asian or Korean ginseng) is one of the most extensively studied herbal adaptogens in the world, with a clinical trial database spanning cognitive function, fatigue, physical performance, immune modulation, and erectile dysfunction. Its active compounds — ginsenosides…
27 Apr 2026
Supplement Guides
At a Glance Saffron (Crocus sativus) has accumulated one of the stronger human clinical trial databases of any botanical for mood support — multiple RCTs have demonstrated antidepressant effects in mild-to-moderate depression, including direct comparisons to fluoxetine and imipramine showing…
27 Apr 2026
Supplement Guides
At a Glance Shilajit is a mineral-rich resin that forms over centuries from the decomposition of plant matter in
27 Apr 2026
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