Evidence. Protocol. Truth.

Protocol

Energy and Fatigue — A Diagnostic-First Protocol

30 May 2026

Protocol

Joint and Tendon Optimization — A Layered Protocol

30 May 2026

Protocol

Anxiety and Mood — A Layered Optimization Protocol

30 May 2026

Protocol

Erectile Dysfunction — A Stepwise Optimization Protocol

30 May 2026

Monograph

Phentermine/Topiramate (Qsymia) — Second-Line Anti-Obesity in the GLP-1 Era

Qsymia is a fixed-dose combination of immediate-release phentermine (a sympathomimetic appetite suppressant) and extended-release topiramate (an anticonvulsant with appetite-reducing properties through multiple mechanisms), FDA-approved in July 2012…

30 May 2026

Monograph

Vuity and Pilocarpine Drops for Presbyopia

Presbyopia — the age-related loss of near vision accommodation that affects essentially all adults by their mid-40s — has been managed historically through reading glasses, bifocals, progressive lenses, contact lens monovision, and surgical…

30 May 2026

Monograph

SSRIs — Long-Term Use and PSSD

Selective serotonin reuptake inhibitors (SSRIs) — fluoxetine, sertraline, citalopram, escitalopram, paroxetine, fluvoxamine — and the closely related SNRIs (venlafaxine, duloxetine) are among the most-prescribed medication classes in modern…

30 May 2026

Monograph

Pelvic Floor Physical Therapy for Men

Pelvic floor physical therapy (PFPT) for men is one of the most under-prescribed, under-recognized evidence-based interventions in men's health. The male pelvic floor — including the levator ani, coccygeus, and supporting muscle groups — is integral…

30 May 2026

Monograph

PSA Testing Strategy and Interpretation

Prostate-specific antigen (PSA) testing has been the central screening tool for prostate cancer since the late 1980s. The history of PSA screening is one of the most-debated topics in cancer screening medicine — early enthusiasm produced substantial…

30 May 2026

Monograph

Microbiome Testing — Viome, ZOE, Sun Genomics

Consumer microbiome testing has emerged as a substantial commercial category over the past decade, with companies including Viome, ZOE, Sun Genomics, Thryve, DayTwo, and various direct-to-consumer offerings sequencing stool samples and returning…

30 May 2026

Monograph

Bisphosphonates Explainer

Bisphosphonates are the most-prescribed and best-evidenced class of osteoporosis treatment. They are synthetic analogs of pyrophosphate (a natural bone-binding compound) that deposit in bone at sites of active resorption. Osteoclasts take up the…

30 May 2026

Monograph

Denosumab (Prolia)

Denosumab (brand name Prolia for osteoporosis, Xgeva for bone metastasis applications, Amgen) is a fully human monoclonal antibody targeting RANKL (receptor activator of nuclear factor κB ligand). RANKL is the principal cytokine driving osteoclast…

30 May 2026