Monograph
Methylene Blue (Topical)
Methylene blue (methylthioninium chloride) is a phenothiazine dye first synthesized in 1876 and used clinically for over a century — as a treatment for methemoglobinemia (FDA-approved indication), as a urinary tract analgesic, and as a surgical dye…
By Kristopher Crawford
·
29 May 2026
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5 min read
Methylene blue (methylthioninium chloride) is a phenothiazine dye first synthesized in 1876 and used clinically for over a century — as a treatment for methemoglobinemia (FDA-approved indication), as a urinary tract analgesic, and as a surgical dye…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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