Kristopher Crawford

Pterostilbene β€” The Resveratrol Analog, the LDL Signal, and Why We No Longer Recommend It

Pterostilbene raised LDL cholesterol by 17.1 mg/dL in the best human RCT (Riche 2014, n=80, P=0.001). The sirtuin/longevity claim has not translated to demonstrated human clinical benefit. Vanguard's revised position: we do not recommend oral pterostilbene supplementation.

13 Apr 2026

Neprinol

Proprietary systemic enzyme blend for proteolytic and fibrinolytic support

13 Apr 2026

NAD+ Precursors (NMN/NR)

Cellular energy currency and sirtuin activator with evolving regulatory status

13 Apr 2026

NAC (N-Acetyl Cysteine)

Cellular antioxidant and glutathione precursor for robust defense

13 Apr 2026

Lysine

An essential amino acid supporting collagen synthesis, immune function, and herpes simplex virus management

13 Apr 2026

Leucine

An essential branched-chain amino acid crucial for muscle protein synthesis and metabolic signaling

13 Apr 2026

Inulin

A prebiotic fiber supporting gut microbiota, digestive health, and metabolic markers

13 Apr 2026

HMB (Beta-Hydroxy Beta-Methylbutyrate)

A leucine metabolite supporting muscle protein synthesis and exercise recovery with solid clinical evidence

13 Apr 2026

Fadogia Agrestis

A traditional West African plant with limited regulatory guidance and concerning preclinical safety signals requiring clinical oversight

13 Apr 2026

Collagen

Hydrolyzed peptides supporting skin, joint, and connective tissue health through targeted amino acid delivery

13 Apr 2026

Boron

An essential trace mineral supporting bone health, hormonal balance, and cognitive function

13 Apr 2026

Berberine

A plant alkaloid with emerging evidence for metabolic and cardiovascular support, requiring clinical context

13 Apr 2026

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