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The carnivore diet — exclusive or near-exclusive consumption of animal products, eliminating all plants — has grown from a fringe practice associated with Shawn Baker and Mikhaila Peterson around 2018 into a major cultural movement with millions of…
29 May 2026
5-Amino-1-methylquinolinium iodide (5-amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. Two metabolic problems flow from…
29 May 2026
Bupropion-naltrexone sustained-release (brand name Contrave) is an FDA-approved combination weight-loss drug, approved in September 2014. It pairs bupropion — a norepinephrine and dopamine reuptake inhibitor used as an antidepressant and…
29 May 2026
Bergamot polyphenolic fraction (BPF) is a standardized extract of the peel and juice of Citrus bergamia, the same fruit responsible for the flavor of Earl Grey tea. The bioactive content is dominated by flavonoid glycosides — neohesperidin,…
29 May 2026
Dual orexin receptor antagonists (DORAs) are the first novel mechanism approved for primary insomnia since the Z-drugs (zolpidem, eszopiclone, zaleplon) entered the market in the 1990s. Three are FDA-approved as of 2026: suvorexant (Belsomra,…
29 May 2026
Salidroside is the most-studied bioactive in rhodiola — and, as of 2024, finally available as a fermentation-derived isolated compound. One small Phase II RCT exists; everything else lives in the whole-extract literature. What the data actually say.
28 May 2026
NMN raises NAD+ levels in humans with solid mechanistic rationale and early clinical data. Updated September 2025: FDA confirmed NMN lawful as a dietary supplement, reversing a 2022 exclusion.
26 May 2026
Four investigational compounds reshaping the weight-loss and metabolic-disease conversation in 2025-2026. What the trials actually showed, where each one differs mechanistically, and how to think about them now versus when they reach the pharmacy.
14 May 2026
Category: Amino Acids Tags: Amino Acids, Nitric Oxide, Cardiovascular, Blood Pressure, Erectile Function Key Takeaways - Arginine is the primary substrate for endothelial nitric oxide synthase (eNOS) and a key driver of nitric oxide (NO)-mediated vasodilation — but citrulline achieves superior…
13 May 2026
Category: Amino Acids Tags: Amino Acids, Sports Performance, Carnosine, Muscle Endurance Key Takeaways - Beta-alanine is the rate-limiting substrate
13 May 2026
Category: Amino Acids Tags: Amino Acids, Muscle Protein Synthesis, Sports Nutrition, Recovery, Leucine Key Takeaways - BCAAs (leucine, isoleucine, valine) acutely
13 May 2026
Category: Amino Acids Tags: Amino Acids, Carnosine, Buffering, Histamine, Anti-inflammatory Key Takeaways - Histidine is a conditionally essential amino acid and the primary amino acid contributor to physiological buffering near neutral pH via its imidazole side chain — the biochemical basis…
13 May 2026
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