Compounds & Therapies
Bisphosphonates Explainer
Bisphosphonates are the most-prescribed and best-evidenced class of osteoporosis treatment. They are synthetic analogs of pyrophosphate (a natural bone-binding compound) that deposit in bone at sites of active resorption. Osteoclasts take up the…
Denosumab (Prolia)
Denosumab (brand name Prolia for osteoporosis, Xgeva for bone metastasis applications, Amgen) is a fully human monoclonal antibody targeting RANKL (receptor activator of nuclear factor κB ligand). RANKL is the principal cytokine driving osteoclast…
Romosozumab (Evenity)
Romosozumab (brand name Evenity, Amgen/UCB) is a humanized monoclonal antibody targeting sclerostin, a protein secreted by osteocytes that inhibits the Wnt signaling pathway in osteoblasts. By neutralizing sclerostin, romosozumab simultaneously…