Compounds & Therapies
N-Acetyl Semax and N-Acetyl Selank
Semax (a synthetic analog of the N-terminal fragment of ACTH 4-10) and Selank (a synthetic analog of tuftsin) were developed by Russian scientific research institutes beginning in the 1980s-1990s. Both are registered medications in Russia for…
Phosphatidylserine: A Practical Guide
Pinealon
Pinealon (Glu-Asp-Arg) is a synthetic tripeptide developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. It is part of the broader Khavinson 'short peptide' bioregulator program, which has…
Polygala Tenuifolia
Polygala tenuifolia (Chinese name: yuan zhi, 远志) is a perennial herb whose root has been used in traditional Chinese medicine for over two thousand years. Classical TCM indications focused on insomnia, restlessness, palpitations, cognitive…
Practices & Lifestyle
Bromantane
Bromantane (N-(2-adamantyl)-4-bromoaniline) is a Russian-developed compound classified as an 'actoprotector' — a class describing agents that increase physical and cognitive performance under stress without the side-effect profile of classical…
NSI-189
NSI-189 is a small-molecule compound developed by Neuralstem (now Seneca Biopharma) as a novel antidepressant working through neurogenic mechanisms — specifically, stimulation of hippocampal neurogenesis. It progressed through Phase 1 and Phase 2…
The Racetam Family
The racetam class — defined by a 2-pyrrolidinone (2-oxopyrrolidinyl) core structure — was the first and remains the most consequential synthetic nootropic class. Piracetam was synthesized by Corneliu Giurgea at UCB Pharma in 1964 and coined the term…