Practices & Lifestyle
Berberine vs Metformin
Metformin is the most-prescribed glucose-lowering medication in the world, with over six decades of clinical use, validated efficacy in type 2 diabetes, an extensive safety database, an emerging longevity literature, and a generic cash price of…
NMN vs NR vs Niacinamide — NAD+ Precursors
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme central to cellular energy metabolism, DNA repair, and sirtuin-mediated signaling involved in aging biology. Circulating and tissue NAD+ levels decline with age in animals and humans. Multiple…
Rapamycin vs Metformin for Longevity
Rapamycin (sirolimus) and metformin are the two off-label drugs most often discussed in the longevity optimization conversation. Both have substantial preclinical evidence for healthspan or lifespan benefit, both have been the subject of ongoing…
Statins vs PCSK9 Inhibitors vs Bempedoic Acid vs Inclisiran
Modern lipid management has four major pharmacological pillars: statins (the dominant first-line therapy), PCSK9 inhibitor monoclonal antibodies (evolocumab and alirocumab, the most potent LDL-lowering option), bempedoic acid (the newer non-statin…
Tirzepatide vs Semaglutide vs Retatrutide
The GLP-1 receptor agonist class has revolutionized obesity medicine over the past five years, but "GLP-1" as a single category obscures three quite different products. Semaglutide (Wegovy for obesity, Ozempic for T2D) is a single GLP-1 receptor…
Tongkat Ali vs Fadogia Agrestis
Tongkat Ali (Eurycoma longifolia) and Fadogia agrestis are the two herbs that have dominated the men's testosterone-supplement conversation since approximately 2020. The pairing was popularized in optimization-medicine influencer content and has…