Trazodone is an FDA-approved antidepressant from 1981 that has, almost entirely off-label, become the most-prescribed sleep medication in the United States. At antidepressant doses (150–600 mg/day), it is an SSRI-era predecessor with a tolerability…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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