Monograph
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c): A Practical Guide
Overview MOTS-c is a 16-amino acid peptide encoded not in the nuclear genome but in the mitochondrial genome — specifically within the 12S ribosomal RNA gene of mitochondrial DNA. It was identified in 2015 by Changhan David Lee and colleagues at the USC Leonard Davis School of Gerontology…
By Kristopher Crawford
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13 May 2026
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4 min read
Overview MOTS-c is a 16-amino acid peptide encoded not in the nuclear genome but in the mitochondrial genome — specifically within the 12S ribosomal RNA gene of mitochondrial DNA. It was identified in 2015 by Changhan David Lee and colleagues at the USC Leonard Davis School of Gerontology…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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