Monograph
Milk Thistle (Silymarin): A Practical Guide
Overview Milk thistle (Silybum marianum) seed extract contains silymarin, a complex of flavonolignans—primarily silybin (silibinin), silydianin, and silychristin—with antioxidant, hepatoprotective, anti-inflammatory, and antifibrotic properties. Silybin is the most biologically active and…
By Kristopher Crawford
·
13 May 2026
·
3 min read
Overview Milk thistle (Silybum marianum) seed extract contains silymarin, a complex of flavonolignans—primarily silybin (silibinin), silydianin, and silychristin—with antioxidant, hepatoprotective, anti-inflammatory, and antifibrotic properties. Silybin is the most biologically active and…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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