Overview Naltrexone at standard doses (50 mg/day) is an FDA-approved opioid receptor antagonist for addiction. Low-dose naltrexone (LDN, 1–5 mg/day) exploits an entirely different mechanism — transient receptor blockade produces rebound upregulation of endogenous opioid signaling and reduces…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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