Monograph
Low-Dose Doxepin (Silenor)
Doxepin is a tricyclic antidepressant that has been on the U.S. market since 1969. At antidepressant doses (75–300 mg/day), it has the classic tricyclic side-effect profile — anticholinergic dry mouth, constipation, urinary retention, orthostatic…
By Kristopher Crawford
·
29 May 2026
·
5 min read
Doxepin is a tricyclic antidepressant that has been on the U.S. market since 1969. At antidepressant doses (75–300 mg/day), it has the classic tricyclic side-effect profile — anticholinergic dry mouth, constipation, urinary retention, orthostatic…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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