Supplements
Lovaza and Vascepa: How the Two Prescription Omega-3s Differ from Each Other and from OTC Fish Oil and Krill Oil
Two prescription omega-3s are commonly confused. Lovaza (EPA+DHA) treats severe hypertriglyceridemia; Vascepa (pure EPA) is the only one with cardiovascular outcomes evidence. Plus: where OTC fish oil and krill oil fit, and the dose-dependent atrial fibrillation signal.
By Kristopher Crawford
Β·
11 May 2026
Β·
18 min read
Two prescription omega-3s are commonly confused. Lovaza (EPA+DHA) treats severe hypertriglyceridemia; Vascepa (pure EPA) is the only one with cardiovascular outcomes evidence. Plus: where OTC fish oil and krill oil fit, and the dose-dependent atrial fibrillation signal.
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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