Monograph
AICAR
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), also called acadesine or simply AICA riboside, is an AMP analog that activates AMP-activated protein kinase (AMPK) — the central cellular energy sensor and metabolic regulator. Activation of…
By Kristopher Crawford
·
30 May 2026
·
5 min read
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), also called acadesine or simply AICA riboside, is an AMP analog that activates AMP-activated protein kinase (AMPK) — the central cellular energy sensor and metabolic regulator. Activation of…
In the full monograph
- What it is, and how it works
- What the evidence shows — randomized trials, observational data, animal studies, graded and cited
- Dose, form, and timing
- What to expect, and how soon
- Who should be careful, and what to check first
- The verdict
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